Effects of a 4-wk high-fat diet on transcriptome and DNA methylation after muscle contractions in rat skeletal muscle
Year: 2026
Type: article
Abstract: This study aimed to identify the effects of a 4-wk HFD on transcriptomic responses to muscle contractions and to examine the association between these transcriptomic changes and DNA methylation in promoter regions. A 4-wk HFD altered the transcriptomic response of specific GOs, including phosphoprotein, MHC II, and extracellular matrix, associated with muscle contractions. However, integrative analysis revealed that these mRNA expression changes were not accompanied by detectable DNA methylation within the regions analyzed in this study.
Source: Physiological Genomics
Authors: Ryo Nehashi, Kentaro Kawata, Yuta Sotani, Tatsuya Kusano, Ryotaro Kano, Reo Takeda, Mizuki Sudo, Yutaka Kano, Daisuke Hoshino
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7204111061