Work

Concurrent Immune-related Enteritis and Cytomegalovirus Enteritis during Immune Checkpoint Inhibitor Therapy

Year: 2026

Type: article

Abstract: Immune checkpoint inhibitors (ICIs) are widely used for advanced lung cancer; however, isolated ileitis and subsequent perforation are rare, particularly when complicated by cytomegalovirus (CMV) infection.A woman in her 50s with stage IV lung adenocarcinoma developed ICI-associated enteritis after atezolizumab-based therapy, which partially improved with corticosteroids and infliximab, but she later experienced ileal perforation following second-line chemotherapy. A histopathological examination revealed ICI-induced enteritis with cytomegalovirus (CMV) inclusions. Despite antiviral therapy with ganciclovir, the patient died. We present the first report of pathologically confirmed ICI-induced ileitis complicated by CMV enteritis in resected small bowel tissue.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.7426-26

Authors: Yuka Yamada, Norio Kodaka, Saeko Shinozawa, Yuki Yokouchi, Hiroto Matsuse

Institution: Toho University Ohashi Medical Center

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7204119808