Work

Dynamic Operations in Macromolecular Data Storage

Year: 2026

Type: article

Abstract: ABSTRACT In recent years, numerous concepts have been reported for storing data on molecules, either small molecule mixtures, oligomer libraries or polymers. In the latter case, binary information is stored in a controlled monomer sequence. This can be achieved in biological polymers such as DNA but also in a variety of synthetic macromolecules. However, most existing approaches focus on passive “cold” storage, in which macromolecules serve as static archives. This minireview explores recent advances in reconfigurable macromolecular storage, highlighting strategies for erasing, rewriting, computing, repairing, or sorting‐out binary‐encoded macromolecules. All these options are discussed herein for both natural and synthetic polymers.

Source: Angewandte Chemie

DOI: 10.1002/ange.5128253

Authors: Jakub Ossowski, Oskar Affenberger, Jean‐François Lutz, Maria Nerantzaki

Institutions: Centre National de la Recherche Scientifique, Institut de Science et d'Ingénierie Supramoléculaires, Université de Strasbourg

Language: English

Topic: DNA and Biological Computing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $5,790

Funder: Agence Nationale de la Recherche