Work

N6-methyladenosine (m6A) RNA modification in muscle stem cells and skeletal muscle regeneration

Year: 2026

Type: article

Abstract: N 6 -methyladenosine (m 6 A) is a highly conserved posttranscriptional modification essential for gene expression, cellular function, and the determination of stem cell fates. As a result, it is regulated by a variety of mechanisms and remains a promising field of study. m 6 A RNA methylation is mediated by multiple classes of proteins, known as writers, erasers, and readers, which are in turn controlled by various transcription factors and regulatory pathways. Dysregulation of these fundamental processes is implicated in a wide range of diseases and disorders, exemplifying their importance in guiding normal physiological activity. In this review, we focused on the effects of m 6 A modification on muscle stem cells (MuSCs), also known as satellite cells, a critical component of skeletal muscle development and regeneration. Further, we evaluated the contemporary literature and expert perspectives to outline the mechanisms of m 6 A RNA methylation, emphasizing their roles in MuSCs and their potential for developing novel therapeutic strategies.

Source: Skeletal Muscle

DOI: 10.1186/s13395-026-00442-5

Authors: Adam Liu, Atsushi Asakura

Institutions: University of California, Los Angeles, University of Minnesota

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890