Work

P‐Directed and Lewis Acid‐Assisted Pd‐Catalyzed Si─Me Bond Activation Enabling Alkyl Exchange at Silicon

Year: 2026

Type: article

Abstract: ABSTRACT A novel mode of Si─Me bond activation has been unveiled through the cooperative action of a P‐directing group, a palladium catalyst and a Lewis acid. The pivotal role of the Lewis acid in enabling the activation of the strong and low‐polarity Si─Me bond was elucidated via stoichiometric experiments. According to DFT calculations, the Lewis acid acts as a Me − acceptor and triggers the formation of the key cationic silyl Pd complex responsible for the alkyl exchange at Si. This unprecedented Si─Me bond transformation has been demonstrated in a four‐step sequence, enabling the stepwise upgrading of Me 3 SiCl into silanols bearing diverse organic substituents.

Source: Angewandte Chemie

DOI: 10.1002/ange.1850136

Authors: Hajime Kameo, Kanta Oishi, Keitaro Yamanaka, Akihiro Mushiake, Hiroyuki Matsuzaka, Didier Bourissou

Institutions: Osaka Metropolitan University, Centre National de la Recherche Scientifique, Laboratoire Hétérochimie Fondamentale et Appliquée, Université de Toulouse

Language: English

Topic: Organoboron and organosilicon chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,790

Funders: Ministry of Education, Culture, Sports, Science and Technology, Université de Toulouse, Centre National de la Recherche Scientifique, Japan Society for the Promotion of Science