A transmembrane protein confers the Yr26/Yr24/YrCH42/YrG22-mediated stripe rust resistance in wheat
Year: 2026
Type: article
Abstract: Stripe or yellow rust (YR), caused by Puccinia striiformis Westend. f. sp. tritici ( Pst ), is a devastating fungal disease of wheat. Here, we report the map-based cloning of Yr26 (synonyms: Yr24 , YrCH42 , and YrG22 ), a major stripe rust resistance gene, and its validation by gene silencing, mutation analysis and transgenic complementation. Yr26 , which firstly arises in emmer wheat and recently has introgressed into bread wheat, is a newly evolved gene encoding a transmembrane protein. AlphaFold v3.0 predictes a C-terminal four-helical bundle domain that is critical for triggering Ca 2+ -dependent cell death, a hallmark of the hypersensitive response. The cloning of Yr26 offers not only a genetic resource for pyramiding stripe rust resistance genes in wheat breeding but also an opportunity to study host–pathogen co-evolution.
Source: Nature Communications
Authors: Shengjie Liu, Keqing Mu, Shuqing Yang, Jianhui Wu, Mingjie Xiang, Xiangrui Cheng, Xiaoting Wang, Yibo Zhang, Ying Zhao, Jiangna Han, Shuo Huang, Haitao Dong, Jiwen Zhao, Fengping Yuan, Raghvendra Sharma, Michael Norman, Peidu Chen, Aizhong Cao, Weijun Zheng, Chunlian Li, Jaroslav Doležel, Kateřina HolušováJ, John Rathjen, Evans Lagudah, Xiaojie Wang, Zhensheng Kang, Sambasivam Periyannan, Dejun Han, Qingdong Zeng
Institutions: Northwest A&F University, Chinese Academy of Sciences, Center for Excellence in Molecular Plant Sciences, Commonwealth Scientific and Industrial Research Organisation, Agriculture and Food, Nanjing Agricultural University, Jiangsu Collaborative Innovation Center for Modern Crop Production, Czech Academy of Sciences, Institute of Experimental Botany, Australian National University, University of Southern Queensland
Language: English
Subfield: Plant Science
Domain: Life Sciences
SDG: Zero hunger
Open Access status: gold
Estimated APC paid: $6,990
OpenAlex ID: W7204149165
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