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The effect of sex and endurance exercise training on the incretin signaling pathway in 17 rat tissues

Year: 2026

Type: article

Abstract: This study provides the first multiomic, multitissue description of incretin signaling receptor expression and regulation in response to endurance exercise training. We identify time point and sex-specific changes in incretin signaling across tissues, highlighting training effects on Gcgr, Gipr, and Sctr regulation in the adrenals, WAT, and brain. These findings help establish an exercise-responsive incretin signaling axis that may identify interactions from incretin-based therapies and exercise-based lifestyle interventions.

Source: Physiological Genomics

DOI: 10.1152/physiolgenomics.00171.2026

Authors: Christopher Jin, Gina Many, Connor Scott Reynoso Spurrier, Philip Borsellino, Matthew T. Wheeler, Joshua N. Adkins, Michael P. Snyder, Christopher B. Newgard, Shlomit Radom-Aizik, Dan M. Cooper, Sue C. Bodine, Simon Schenk, Malene E. Lindholm, the MoTrPAC study group

Institutions: Stanford University, Pacific Northwest National Laboratory, University of California San Diego, Oregon Health & Science University, Duke University, Oklahoma Medical Research Foundation

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Common Fund

Awards: G1893755881, G1980857338, G2242645005, G3696957845, G4244708345, G4658170607, G5478282141, G5863592985, G621270725, G6218998370, G6866592604, G7594342615, G8336916767, G960935192

OpenAlex ID: W7204151608

FWCI:

Cites: 75

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