Against
Year: 2026
Type: article
Abstract: Pre-eclampsia is a pregnancy disorder associated with substantial maternal and perinatal morbidity and mortality worldwide. Low-dose aspirin initiated during the first trimester can reduce the risk of preterm pre-eclampsia, leading some to advocate universal prophylaxis during pregnancy. Although simple in principle, this approach would unnecessarily expose many low-risk women to treatment while providing limited absolute benefit. Moreover, the effectiveness of aspirin depends on treatment adherence, which may be reduced without individualized risk assessment. Current evidence supports targeted aspirin prophylaxis following first-trimester risk stratification rather than universal treatment, an approach that has not been evaluated in adequately powered randomized trials.
Source: Clinical Obstetrics & Gynecology
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7204159707