Engineering Supramolecular {HAT(CN) 6 ;Oligoresorcinol;Anion} Synthons and Knots via Cooperating Multimodal Noncovalent Interactions
Year: 2026
Type: article
Abstract: ABSTRACT The interplay of multiple noncovalent interactions offers a powerful strategy for the design of functional supramolecular architectures. Here, we developed a unique series of ternary cocrystal salt‐like {coformer1;coformer2;salt} systems in the solid state and in solution to approach the problem of collective binding of halide (Cl − , Br − ) or pseudohalide (SCN − ) anion pairs. Exploiting HAT(CN) 6 π‐acid (coformer1) and oligoresorcinol hydrogen‐bond donors (coformer2), we identify five new ternary {coformer1;coformer2;[anion] n } ( n = 1–2) supramolecular synthons that integrate anion–π interactions, π–π stacking, and hydrogen bonding, reflecting the intrinsic preferences of components. SC XRD and solution 1 H/ 13 C NMR studies demonstrate transferability of the synthons among the relevant binary and ternary crystal phases, as well as between the solid state and solution. DFT+D computational analysis confirms the contribution of all three types of supramolecular interactions to the formation and stability of observed motifs, showing a variable hierarchy of these forces modulated by the structural and electronic features of building blocks. Our results demonstrate that while crystal packing influences solid‐state arrangements, system's integrity arises from a balance of cooperation and competition among noncovalent interactions. This establishes a new library of complex supramolecular synthons for further consideration in overall supramolecular design.
Source: Chemistry - A European Journal
DOI: 10.1002/chem.71501
Institutions: Jagiellonian University, Nicolaus Copernicus University
Language: English
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7204166989