APOE2 attenuates APOE4-associated amyloid pathology and related toxicity
Year: 2026
Type: article
Abstract: This repository contains the analysis scripts used in the study investigating the effects of heterozygous APOE genotypes in a 5xFAD mouse model of amyloid pathology. The study examines how APOE2 and APOE4 influence amyloid deposition, glial responses, proteomic profiles, and lipidomic alterations, with particular focus on whether APOE2 is associated with attenuation of APOE4-related pathological and molecular changes in APOE2/4 mice.
Authors: Chen, Kai, Chen, Yixing, Ren, Yingxue, Wang, Zhen, Huang, Ya, Pan, Meixia, Li, Zonghua, Casey, Monica Castanedes, Qiao, Wenhui, Shi, Ji, Kong, Dehui, Xhafkollari, Gisela, Santhakumar, Hannah, Wetmore, Allison M., Thompson, E. Aubrey, Wang, Xusheng, Dickson, Dennis W., Holtzman, David M., Bu, Guojun, Han, Xianlin, Peng, Junmin, Zhao, Na
Institutions: Mayo Clinic, Mayo Clinic in Florida, St. Jude Children's Research Hospital, The University of Texas at San Antonio Health Science Center, Mayo Clinic Comprehensive Cancer Center (Florida), University of Tennessee Health Science Center, Washington University in St. Louis, Hope Center for Neurological Disorders, Hong Kong University of Science and Technology
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7204168738
FWCI:
Cites:
Cited by:
Related to: