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Recent Advances in Enantioselective Desymmetrization Enabled by Chiral Phosphoric Acid Catalysis

Year: 2026

Type: article

Abstract: Enantioselective desymmetrization represents an efficient strategy for accessing enantioenriched products from relatively simple achiral starting materials, and it has been widely recognized as a pivotal approach in asymmetric synthesis. As one of the most versatile organocatalysts identified to date, chiral phosphoric acids (CPAs) have been extensively applied in the aforementioned research field. In this review, we summarized the substantial advances in enantioselective desymmetrization reactions enabled by CPA catalysis. Additionally, representative cases involving CPAs as cooperative catalysts are also discussed in detail.

Source: Chirality

DOI: 10.1002/chir.70141

Authors: Dekun Zhang, Dekun Zhang, Bubin Xu, Yuxiu Yang, Ding Zhang, Ding Zhang

Institution: Jiangxi Science and Technology Normal University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Jiangxi Science and Technology Normal University

OpenAlex ID: W7204172681

FWCI:

Cites: 72

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