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Direct Measurement of Protein Corona Thickness on Nanomaterials Using Dual‐Color Stochastic Optical Reconstruction Microscopy (STORM) (Small Methods 16/2026)

Year: 2026

Type: article

Abstract: Inside Front Cover By labeling the surfaces of nanoparticles and the outer edge of adsorbed protein coronas with spectrally distinct fluorophores, dual-color STORM was used to measure protein corona thicknesses. These detailed measurements revealed a remarkably consistent thickness of ∼50 nm across different types of particles. Accurate measurement of how the protein corona thickness changes in different environments is crucial to understanding how nanoparticles act in biological media. More in article number e02394, Christopher C. Landry, and co-workers.

Source: Small Methods

DOI: 10.1002/smtd.70939

Authors: Bradley T. Cech, Sophie M. Sullivan, Christopher C. Landry

Institution: University of Vermont

Language: English

Topic: Advanced Fluorescence Microscopy Techniques

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W7204175321

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