Work

Early Temporal Dissociation Between C-Reactive Protein and Neutrophil Counts After Spesolimab Treatment in Generalized Pustular Psoriasis

Year: 2026

Type: article

Abstract: Generalized pustular psoriasis (GPP) is a rare and severe inflammatory disease characterized by widespread sterile pustules and systemic manifestations.In addition to cutaneous symptoms, GPP is associated with systemic inflammation, as reflected by fever, elevated white blood cell (WBC) and neutrophil counts, increased serum C-reactive protein (CRP) level and decreased serum albumin level.Since GPP can be life-threatening, rapid control of systemic inflammation is essential.Spesolimab, a monoclonal antibody targeting the interleukin (IL)-36 receptor, has demonstrated efficacy in GPP flares (1), and our previous realworld study showed rapid clinical improvement, particularly in pustular lesions (2).However, day-to-day changes in systemic inflammatory markers after spesolimab treatment remain unclear.Therefore, we aimed to evaluate the early effects of spesolimab on systemic inflammatory markers during the first 14 days of treatment in patients with GPP.

Source: Acta Dermato Venereologica

DOI: 10.2340/actadv.v106.adv-2026-0804

Authors: Ayu Watanabe, Masahiro Kamata, Yoshiki Okada, Kotaro Hayashi, Yayoi Tada

Institution: Teikyo University

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,725