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Cover Feature: Extending Cofactor‐Tethered Nanomachines to Complex Multienzyme Redox Cascades in Continuous Flow (ChemSusChem 17/2026)

Year: 2026

Type: article

Abstract: The Cover Feature places cofactor-tethered fused-enzyme nanomachines in the spotlight, connecting molecular-scale design with industrial-scale biocatalysis. The continuous-flow reactor represents the reliance of conventional redox enzyme cascades on freely diffusing, valuable nicotinamide cofactors, whereas the nanomachine strategy retains and recycles these cofactors to support cofactor-autonomous operation, advancing sustainable biomanufacturing. More information can be found in the Research Article by V. Sieber and co-workers (DOI: 10.1002/cssc.70914).

Source: ChemSusChem

DOI: 10.1002/cssc.71009

Authors: Zinnia Dsouza, Jan‐Simon Jeshua Friedrichs, Okke Melse, Gerhard Schenk, Volker Sieber

Institutions: Technical University of Munich, The University of Queensland

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W7204212253

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