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Endocannabinoids facilitate reward engagement through retrograde gain control

Year: 2026

Type: article

Source: Nature

DOI: 10.1038/s41586-026-10967-w

Authors: David J. Marcus, Anthony E. English, Gunn Chun, Emmaline F. Seth, Rachel Oommen, Sabrina Hwang, Bailey A. Wells, Sean C. Piantadosi, Azra Suko, Sayaka J. Kenmochi, Anupritaa A. Parasnis, Ethan Ancell, Yulong Li, Larry S. Zweifel, Benjamin B. Land, Nephi Stella, Michael R. Bruchas

Institutions: University of Washington, Peking University

Language: English

Topic: Cannabis and Cannabinoid Research

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Washington, National Institutes of Health, National Institute of Mental Health, National Center for Complementary and Integrative Health

Awards: Cannabidiol and terpenoid interactions in amygdalar regulation of pain states, Role of CB1R expressed in the prefrontal cortex in the control of locomotion, Neurotensinergic-eCB modulation of reward and aversion via a PVT-NAc circuit, G3195602816, G4138977392, G4480946400, Differential control of 2-AG’s activity at CB1R by ABHD6 and MAGL, Endocannabinoid modulation of behavioral engagement via an aPVT-NAc circuit, Decoding Locus Coeruleus Neural Circuits and Signaling In Negative Affect, DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCE

OpenAlex ID: W7204220924

FWCI:

Cites: 67

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