Work

The Current Landscape of Pulmonary Hypertension in Myeloproliferative Neoplasms

Year: 2026

Type: article

Abstract: Pulmonary hypertension (PH) is an increasingly recognized complication of Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). Recent data suggest prognostic implications of both cardiovascular morbidity and mortality and hematologic progression. Additionally, PH and MPNs share common pathophysiologic mechanisms that bridge these two seemingly different disorders. The landscape of PH in MPNs is evolving in the face of improved survivorship and reduced disease progression, leading to increased incidence and prevalence of concurrent and/or consequent cardiovascular disease. Prospective studies are necessary to refine screening protocols, risk stratification, and prognostic and therapeutic implications of PH in this population.

Source: Cancers

DOI: 10.3390/cancers18172775

Authors: Monica Ferrante, Hyeon-Ju Ali, Gabriela Hobbs, Orly Leiva

Institutions: University of Kentucky, The University of Texas MD Anderson Cancer Center, Harvard University, Massachusetts General Hospital, Mass General Brigham

Language: English

Topic: Myeloproliferative Neoplasms: Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499