Cognitive function predicts all-cause mortality independent of social engagement among community-dwelling elderly Japanese men: a 15-year prospective cohort study
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: As the global population ages, cognitive impairment has become a growing public health concern. Although epidemiological studies have examined its association with mortality, sex-stratified analyses and community-based investigations in elderly Asian men remain scarce. Furthermore, social engagement may confound the association between cognitive impairment and mortality; yet few studies among community-dwelling elderly Asian men have simultaneously examined cognitive impairment and social engagement in relation to all-cause mortality in a prospective cohort design. This study therefore aimed to examine whether cognitive impairment is associated with an increased risk of all-cause mortality independent of social engagement among community-dwelling elderly Japanese men over a 15-year follow-up period. METHODS: This prospective cohort study enrolled 2,174 men aged ≥65 years. Follow-up assessments were conducted at five, ten, and fifteen years, with all-cause mortality as the primary outcome. Cognitive function was assessed using the Mini-Mental State Examination. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards models to examine the association between cognitive function and all-cause mortality. Confounder-adjusted Kaplan-Meier survival curves were generated using inverse probability of treatment weighting. RESULTS: The final analytic sample comprised 1,741 men. High social engagement was associated with a lower risk of all-cause mortality. Compared with participants with normal cognitive function, the hazard ratios (HRs) for all-cause mortality were 1.29 (95% CI: 1.06-1.56) for mild cognitive impairment and 1.59 (95% CI: 1.10-2.29) for severe cognitive impairment, after adjusting for potential confounding factors including social engagement. CONCLUSIONS: Cognitive impairment independently predicts an increased risk of all-cause mortality in community-dwelling elderly Japanese men.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,145
Awards: Are lower levels of osteocalcin associated with increased risk of incident type 2 diabetes mellitus and metabolic syndrome?, Does osteocalcin, a bone formation marker, predict future development of diabetes mellitus? A large-scale cohort study, The development of a fracture risk assessment model focusing on lower limb muscle mass -Epidemiological study of Japanese men-, G1564566340, A follow-up study of the combined effects of muscle mass and strength on falls in community-dwelling older adults., G1642921554, G2196993068, G2380031095, A five-year follow-up of Japanese male cohort for prevention of osteoporotic fracture and its related diseases on the basis of fracture risk assessment, The predictive ability of osteoporotic fractures for a risk of cardiovascular disease based on organ crosstalk :10-years follow-up of a cohort study for osteoporosis risk in men., G2761971237, G2783776567, G281918849, G3514114876, G3835123102, G3878927270, Independent and combined effects of prevalent vertebral fracture and coronary risk factors on disability-free survival, G46006576, A large-scale long-term cohort study contributing extension of healthy life expectancy based on the bone-disease cross-talk, The predictive ability of endogenous secretory receptor for advanced glycation end products for fragility Fractures and cardiovascular diseases., Measurement significance of bone quality index undercarboxylated osteocalcin in the risk evaluation of the male bone fracture, Does low level of serum CTRP3 increase the risk of osteoporosis and fragility fractures?, Nursing Model for life-related Disease Prevension:Based on the Results of a 10-year Follow-up Study, Validation and improvement of a prediction model for osteoporotic fractures, FRAX, in a large-scale cohort of Japanese elderly men., G6891297873, G7621232575, 骨格筋量による骨折発生の予測：高齢男性骨粗鬆症コホートの４から８年後追跡研究, 大腿骨近位部の包括的骨強度評価に向けての同部骨構造解析法の日本人への適用, The fracture risk assessment tool using bone mineral density, risk factors and biochemical marker of bone turnover, G897371700
OpenAlex ID: W7204232537