Work

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Year: 2026

Type: article

Abstract: Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune responses dominate the entire AAA pathological process, and multiple immune cells regulate vascular homeostasis and disease progression via cytokine secretion. Methods This study systematically reviewed current literature to elaborate the infiltration and functions of macrophages, neutrophils and T cells in AAA, and summarized immune cell phenotypic imbalance and core regulatory mechanisms. Results We clarified the immune cell interaction network in AAA, generalized updated immune‐targeted intervention strategies, and sorted out major controversies in existing related studies. Conclusions This review highlights immune‐mediated AAA pathogenesis and research gaps, providing theoretical support for subsequent AAA basic research and novel immune‐targeted drug development.

Source: Clinical and Translational Discovery

DOI: 10.1002/ctd2.70200

Authors: Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen

Institution: Zhongnan Hospital of Wuhan University

Language: English

Topic: Aortic aneurysm repair treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,420