Cobalt(II) and Nickel(II) Complexes of a New 2,6‐Di(pyrazin‐2‐yl)pyridine Ligand: Synthesis, Crystal Structures, Serum Albumin Interactions, and Antiproliferative Activity
Year: 2026
Type: article
Abstract: Two new transition‐metal complexes based on a dipyrazinylpyridine (dppy) ligand, 4‐( tert ‐butoxyphenyl)‐2,6‐di(pyrazin‐2‐yl)pyridine ( L ), namely {[Co L 2 ](ClO 4 ) 2 ( 1 ) and [Ni L 2 ](ClO 4 ) 2 ( 2 )}, were synthesized and characterized using various spectroscopic techniques. Single‐crystal X‐ray diffraction analysis revealed that complexation occurs in a 1:2 metal‐to‐ligand stoichiometry and both complexes exhibit distorted octahedral geometries. Furthermore, the binding studies with serum albumins (human serum albumin [HSA] and bovine serum albumin [BSA]) revealed that the complex 2 shows greater affinity than complex 1. Emission spectra showed binding constants of 3.83 × 10 4 M −1 and 2.63 × 10 7 M −1 for complex 1 and 2 , respectively, with BSA, whereas the corresponding values for HSA were 2.57 × 10 3 M −1 and 1.41 × 10 7 M −1 , respectively. Fluorescence quenching tests revealed a static quenching mechanism. The anticancer activity of the complexes was evaluated against Dalton’s lymphoma (DL) cells by MTT assay after 24–96 h of treatment at half IC 50 concentrations. Complexes 1 and 2 showed IC 50 values of 45 and 157 µM, respectively, indicating enhanced cytotoxic potency of complex 1 against DL cells.
Source: ChemPhotoChem
DOI: 10.1002/cptc.70261
Institutions: National Institute Of Technology Silchar, Cotton University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Arthritis National Research Foundation, Indian Institute of Technology, Patna, National Research Foundation, Department of Biotechnology, Ministry of Science and Technology, India, Indian Institute of Technology Madras, National Institute of Technology Rourkela, National Institute of Technology, Silchar
Award: G2813393735
OpenAlex ID: W7204238357