Work

Efficient and General Synthesis of 2‐Substituted 2‐Methyl 2 H ‐Chromenes Under Lewis Acid‐Catalyzed Conditions

Year: 2026

Type: article

Abstract: ABSTRACT An efficient and operationally straightforward approach has been developed for the synthesis of 2‐allyl‐2‐methyl‐2 H ‐chromenes under Lewis acid‐mediated conditions. The reaction proceeds via initial isomerization of the ( E )‐double bond in the enone substrate, followed by intramolecular cyclization and nucleophilic trapping. This cascade sequence offers several notable advantages, including mild reaction conditions, sequential isomerization with concurrent formation of both C–O and C–C bonds in a single step, the use of readily accessible reagents, broad substrate tolerance toward electron‐donating and halo substituents, and good to excellent isolated yields.

Source: Journal of Heterocyclic Chemistry

DOI: 10.1002/jhet.70243

Authors: Aedula Vishnu V. Reddy, Gheya Bharathi Tammu, Debendra K. Mohapatra

Institutions: Indian Institute of Chemical Technology, Academy of Scientific and Innovative Research

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Department of Science and Technology, Ministry of Science and Technology, India

Award: G286468109