Human Papillomavirus Vaccine Effectiveness Against Prevalent Human Papillomavirus by Age, Years Sexually Active Before Vaccination, and HIV Status in Gay, Bisexual, and Other Men Who Have Sex With Men, 2019–2021
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: We compared the prevalence of vaccine-preventable anal human papillomavirus (HPV) types among gay, bisexual, and other men who have sex with men (GBM) living in large cities in Canada from 2019 to 2021 by age and HIV status. METHODS: Sexually-active GBM ≥16 years were recruited in Montreal, Toronto, and Vancouver using respondent-driven sampling (RDS). Participants self-reported HPV vaccination and self-collected anal HPV specimens. We estimated the prevalence of vaccine-preventable types for participants during the 2019 to 2021 period. We report RDS-II-weighted prevalence and confounder-adjusted prevalence ratios (aPRs) comparing vaccinated (≥1 dose) and unvaccinated GBM using multivariable Poisson regression. RESULTS: Among 1,159 participants aged 18-83 (median 35 years), 17.6% were living with HIV, and 62.2%, 40.2% and 15.0% were vaccinated in the 16-26, 27-45, and ≥46-year groups, respectively. Among GBM 16-26 years, HPV6/11/16/18 prevalence was lower among those vaccinated ≤23 years (aPR= 0.40, 95% CI: 0.20-0.77), ≥3 years since first dose (aPR=0.39; 95% CI: 0.18-0.85), and those with ≤5 years of sexual activity before vaccination (aPR=0.47; 95%CI: 0.25-0.89). HPV6/11/16/18/31/33/45/52/58 prevalence was lower among those vaccinated ≤26 years in GBM aged 27-45 years (aPR= 0.81, 95% CI, 0.61-1.08), though this did not reach statistical significance. CONCLUSIONS: Five years after implementation of Canadian HPV vaccination programs for younger GBM, anal HPV prevalence was lower among those vaccinated at younger ages and near sexual debut.
Authors: Pranamika Khayargoli, Daniel Grace, Joseph Cox, Alexandra de Pokomandy, Troy Grennan, Trevor A Hart, Rahim Moineddin, David M Moore, Catharine Chambers, Shelley L Deeks, Ramandip Grewal, Jody Jollimore, Nathan J Lachowsky, Rosane Nisenbaum, Gina Ogilvie, Chantal Sauvageau, Darrell H S Tan, Anna Yeung, Terri Zhang, François Coutlée, Ann N Burchell
Institutions: St. Michael's Hospital, University of Toronto, Unity Health Toronto, McGill University, McGill University Health Centre, Research Institute of the McGill University Health Centre, University of British Columbia, BC Centre for Disease Control, Toronto Metropolitan University, University of Northern British Columbia, Institute for Clinical Evaluative Sciences, BC Centre for Excellence in HIV/AIDS, Public Health Ontario, Dalhousie University, Community Based Research Centre, University of Victoria, Institut National de Santé Publique du Québec, Université Laval, Centre de recherche du CHU de Québec-Université Laval, Centre Hospitalier de l’Université de Montréal, Université de Montréal
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,763
Awards: How is biomedical HIV prevention changing risk behaviour among gay and bisexual men? A multisite cohort study., G1744498712, G1901548210, G2123497668, G3111043720, Addressing Recent Trends in HIV Among Gay, Bisexual, and other Men Who Have Sex with Men in Vancouver, British Columbia, G969790876
OpenAlex ID: W7204255559