Real-time microcirculatory monitoring during intradialytic exercise using an earlobe laser Doppler flowmeter: an exploratory preliminary study
Year: 2026
Type: article
Abstract: Background Intradialytic exercise is recommended to improve exercise capacity, physical function, and quality of life in patients undergoing maintenance hemodialysis (HD). However, objective and practical physiological indicators for monitoring circulatory responses during intradialytic exercise remain limited in routine clinical settings. Laser Doppler flowmeter (LDF) enables noninvasive assessment of microcirculatory blood flow and may provide a useful method for monitoring peripheral circulation during exercise. This study aimed to investigate changes in earlobe microcirculatory blood flow during intradialytic exercise using LDF and to evaluate its association with perceived exercise intensity. Methods Seventeen patients undergoing maintenance HD participated in this observational study. A 20-minute intradialytic exercise program consisting of lower-limb resistance and stretching exercises was performed during dialysis sessions. Bilateral earlobe blood flow and pulse rate were continuously measured using LDF. Relative changes from baseline were calculated at 5-minute intervals (5, 10, 15, and 20 minutes). The stability index (SI), defined as the coefficient of variation of the blood flow signal, was calculated to evaluate microcirculatory stability. Perceived exertion was assessed using the modified Borg scale. Statistical analyses included paired t-tests, Wilcoxon signed-rank tests, and Pearson correlation analysis. Results Earlobe blood flow increased significantly during intradialytic exercise compared with baseline, reaching a maximum increase of approximately 1.9-fold of the resting level. A strong positive correlation was observed between earlobe blood flow and perceived exertion assessed by the Borg scale (r = 0.938, p < 0.001). Despite the increase in blood flow, the stability index did not change significantly during exercise, indicating that microcirculatory fluctuations remained stable throughout the exercise period. Conclusion Earlobe blood flow increased during intradialytic exercise and correlated with perceived exertion, while microcirculatory variability remained stable. These findings indicate that earlobe blood flow may reflect acute peripheral circulatory responses to exercise. However, given the study’s limitations, including small sample size and lack of control conditions, further studies are needed to validate its clinical applicability.
Source: Renal Replacement Therapy
Authors: Makoto Saito, Hideto Tanaka, Miki Matsui, Kazuyoshi Karasuda, Yoko Kato
Institution: Gumma Paz College
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7204257275