Work

Anastomotic Urethroplasty is Associated with a Lower Risk of Stricture Recurrence Compared with Buccal Mucosa Graft Onlay After Reconstruction for Radiation-Induced Bulbomembranous Urethral Stenosis

Year: 2026

Type: article

Abstract: PURPOSE: The preferred treatment of bulbomembranous urethral stenosis (BMUS) after prostate cancer radiotherapy remains unclear. The purpose of this study was to examine the association of surgical technique and outcomes after urethroplasty for radiation-induced BMUS. MATERIALS AND METHODS: From January 2001 to September 2024, a review of patients undergoing posterior urethroplasty for BMUS at 2 centers was performed. The primary outcome was stricture recurrence defined as stricture < 16Fr confirmed on cystoscopy. Secondary outcomes included 90-day complications (Clavien ≥ 2), patient-reported satisfaction, de novo erectile dysfunction, or incontinence. Cox regression was used to evaluate variables associated with stricture recurrence, and Fisher exact test was used for secondary outcomes. RESULTS: = 1.0). CONCLUSIONS: When technically feasible, anastomotic urethroplasty is associated with a lower risk of stricture recurrence compared with onlay with buccal mucosa when reconstructing radiation-induced bulbomembranous urethral stenosis without a higher risk of adverse events.

Source: The Journal of Urology

DOI: 10.1097/ju.0000000000005279

Authors: Keith Rourke, Joel Gelman

Institutions: University of Alberta, University of California, Irvine

Language: English

Topic: Urological Disorders and Treatments

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,000