Year: 2026
Type: article
Study design: Case Report
Abstract: Anogenital mammary-like glands (AGMLG) are specialized glands of the anogenital region capable of giving rise to lesions analogous to those of the breast. Fibroadenomas arising from AGMLG are well documented in the vulva but are exceedingly rare in male genital anatomy. We report a penile fibroadenoma arising from AGMLG in a 29-year-old transgender woman with a progressively enlarging mass while receiving feminizing hormone therapy. Histologic examination demonstrated a well-circumscribed fibroepithelial lesion with intracanalicular architecture, ductal structures with a bilayered epithelium, and paucicellular stroma without atypia. Immunohistochemistry supported mammary-type differentiation. This case highlights the importance of recognizing AGMLG-derived lesions and their morphologic overlap with breast counterparts.
Source: Journal of Cutaneous Pathology
DOI: 10.1111/cup.70189
Authors: Tamar Gomolin, David Jou, Abdelsalam Sharabi
Institution: Icahn School of Medicine at Mount Sinai
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7204269497