Work

Effect of Sodium C-Tetra(propyl)resorcin[4]tetrasulfonate (Na4PRA) on Antituberculosis Drugs as Seen by Diffusometry and NMR Spectroscopy

Year: 2026

Type: article

Abstract: The present study investigates the physicochemical behavior of the first-line anti-tuberculosis drugs isoniazid (INH) and ethambutol, in the form of dihydrochloride (E·(HCl)2), in aqueous solutions containing the synthetic macrocyclic resorcinarene, C-tetra(propyl)resorcin[4]tetrasulfonate (Na4PRA) at 298.15 K. Taylor dispersion experiments were conducted to determine the ternary diffusion coefficients of these systems, offering valuable insights into their transport properties. Non-zero cross-diffusion coefficients (D12 and D21) demonstrate significant coupled transport, collectively indicating interactions between these antibiotics and the resorcinarene host. This behavior is highly consistent with the formation of a host–guest complex. These diffusion measurements were complemented by NMR spectroscopy, which confirmed the formation of host–guest complexes between the respective drugs and this resorcinarene, Na4PRA.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms27177657

Authors: Edilma Sanabria, Ana C. F. Ribeiro, Ana M. T. D. P. V. Cabral, Mauricio Maldonado

Institutions: Universidad Manuela Beltrán, University of Coimbra, Universidad Nacional de Colombia

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,499

Funders: Universidad Nacional de Colombia, Universidade de Coimbra, Fundação para a Ciência e a Tecnologia