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Related Data for: Dose response of leucine intake on muscle preservation during weight loss in young adult men: A randomized controlled trial

Year: 2026
Type: dataset
Abstract: Background: Obesity is a global public health crisis. While weight loss protocols like alternate-day fasting (ADF) effectively reduce body mass, they often cause significant muscle loss. Research suggests that leucine may better preserve muscle than protein, stimulating muscle protein synthesis with far fewer calories than protein, making it ideal during weight loss. However, the optimal dose for leucine is unclear. Objective: This study investigates how body-mass-adjusted leucine intake affects body composition and health biomarkers during ADF. By controlling total dietary, protein, and leucine intake, this study aimed to identify an optimal dose-response relationship. Methods: Eighty young men (BMI ≥ 23.0 kg/m2) were randomly assigned to one of four groups based on leucine intake (0.02, 0.04, 0.06, and 0.08 g/kg/meal). They underwent four weeks of ADF, alternating between feeding and fasting days (125% and 25% of caloric needs, respectively). Body composition was assessed using dual-energy x-ray absorptiometry. Health biomarkers—resting blood pressure, lipid profile, fasting blood glucose, insulin, and insulin resistance—were also assessed. Results: There were no significant interaction effects for any body composition or health measure (p > 0.05), except for HDL cholesterol (p = 0.028). There were significant main effects of time (p < 0.05) with reductions in all body composition measures and other biomarkers, except for bone mineral density (p = 0.992). Conclusions: ADF is safe and effective for weight loss, cardiovascular and diabetic health in young men. Increasing body-mass-adjusted leucine intake failed to further improve body composition, muscle preservation, or health markers.
DOI: 10.25340/r4/5vbyvt
Subfield: Cell Biology
Open Access status: green
OpenAlex ID: W7204272557
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