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Additional file 5 of CCL5 and CD11b-fibrin interactions regulate microglia migration and morphology in hyperinflammatory experimental cerebral malaria

Year: 2026

Type: other

Abstract: Supplementary Material 5: Supplemental Figure 5: Platelet depletion in fibrinogen-deficient animals does not change eCM symptoms. Fga KO mice were infected with 10^6 P. berghei ANKA iRBC followed by anti-mouse GPIb(α) (CD42b) or isotype control to deplete platelets (3, 5, and 6 dpi, i.p.). A) SHIRPA behavioral clinical score, B) Weight change (% change), C) Survival curve, D) Parasitemia (iRBC/RBC). Data are presented as the mean with 95% CI, and were tested using 2-way ANOVA, followed by the Sidak multiple comparisons test, except for survival curves, analyzed using the Log-rank (Mantel-Cox) test. ns, not significant.

Source: Figshare

DOI: 10.6084/m9.figshare.33346706

Authors: Nadia D. Domingo, Olivia D. Solomon, Paula Villarreal, Florentin Aussenac, Difernando Vanegas, Mark Joseph Endrino, Andrew S. Mendiola, Lucinda Puebla-Clark, Komi Gbedande, Astrid E. Cardona, Katerina Akassoglou, Matthew J. Flick, Gracie Vargas, Robin Stephens

Institutions: Prairie View A&M University, The University of Texas Medical Branch at Galveston, The University of Texas at San Antonio, Gladstone Institutes, University of California, San Francisco, University of North Carolina at Chapel Hill, University of Southern Denmark

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7204444062

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