Work

Shared ligand-blocking mechanism but distinct conformational modulation by α5-targeting antibodies BIIG2 and MINT1526A

Year: 2026

Type: article

Source: Structure

DOI: 10.1016/j.str.2026.08.001

Authors: Adam Nguyen, Joel B. Heim, Gabriele Cordara, Matthew C. Chan, Hedda Johannesen, Cristine Charlesworth, Ming Li, Caleigh M. Azumaya, Benjamin Madden, Ute Krengel, Alexander Meves, Melody G. Campbell

Institutions: University of Washington, Fred Hutch Cancer Center, Mayo Clinic, University of Oslo

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Mayo Clinic, Pew Charitable Trusts, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences

Awards: High-Performance Compute Cluster for Comprehensive Cancer and Infectious Diseases Research, Precision Medicine by Targeting Cell Adhesion in Melanoma, Structural Mechanism of Activation and Modulation of Tie2-mediated Angiogenesis, Mayo Clinic Comprehensive Cancer Center Support Grant, Cancer Center Support Grant, The Molecular Basis for Integrin-Mediated Bidirectional Signaling, Interdisciplinary Training in Cancer Research

OpenAlex ID: W7204446985

FWCI:

Cites: 131

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