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Dichloramine B: A Reagent for Regioselective Chloroalkoxylation of 3‐Aryloxindoles

Year: 2026
Type: article
Abstract: A catalyst‐ and additive‐free strategy for the direct chloroalkoxylation of 3‐aryloxindoles has been developed using dichloramine B as a readily available electrophilic chlorinating reagent and alcohols as alkoxy nucleophiles. Notably, dichloramine B is converted to benzenesulfonamide during the chloroalkoxylation process, which is regenerated to dichloramine B with Cl 2 in industry. This mild, operationally simple protocol affords aromatic‐chloro‐3‐alkoxyoxindoles with excellent regioselectivity and broad functional‐group tolerance.
DOI: 10.1002/adsc.70733
Authors: Niuniu Li, Lina Huang, Teck‐Peng Loh, Dechang Han, Rong‐Bin Hu, Lijuan Liang, Peng Chen, Zhenhua Jia
Language: English
Field: Chemistry
Open Access status: bronze
Funders: Agency for Science, Technology and Research, Nanyang Technological University, National Natural Science Foundation of China, Henan University of Technology, Henan University, Science and Technology Department of Henan Province
Awards: G1001996192, G1396589321, G4640256253, G5545714343, G5575621636, G7002477465, G8054798955, G8360469645
OpenAlex ID: W7204447053
FWCI:
Cites: 23
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