Integrating toxicogenomics into the Saudi Genome Program 2.0: Opportunities and long-term impact
Year: 2026
Type: article
Abstract: Toxicogenomics (TGx) integrates toxicology with high-throughput omics technologies to elucidate the molecular mechanisms underlying adverse responses to chemical and environmental exposures. Advances in TGx are transforming risk assessment, drug development, and regulatory decision-making by enabling early detection of toxicity. In Saudi Arabia, the expansion of the Saudi Genome Program 2.0 (SGP 2.0) as part of the National Biotechnology Strategy, represents a key opportunity to embed TGx within a national precision health framework. Integrating TGx into the SGP 2.0 can generate population-specific data that link genetic variability with susceptibility to environmental exposures, thereby supporting evidence-based policymaking and disease prevention strategies. Such integration aligns with the goals of Vision 2030 and the health sector transformation program on increasing life expectancy, reducing the burden of noncommunicable diseases, and improving overall wellbeing and quality of life. Moreover, TGx can strengthen regulatory science by supporting next-generation risk assessment approaches, facilitating chemical read-across, and reducing reliance on animal testing. This article discusses the scientific rationale, strategic value, and regulatory implications of incorporating TGx into the SGP 2.0. The discussion highlights examples of how TGx can advance personalized medicine, environmental health protection, and sustainable biomedical innovation.
Authors: Nasser B. Alsaleh, Homood M. As Sobeai
Institution: King Saud University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7204454109