Work

MIR99AHG suppresses lung cancer progression by restricting SCD1-dependent lipid biogenesis

Year: 2026

Type: article

Abstract: Long non-coding RNAs (lncRNAs) are important regulators of tumor progression, but their roles in lipid metabolic reprogramming remain incompletely defined. Here, we identified MIR99AHG as a downregulated lncRNA in lung cancer. Functional assays showed that MIR99AHG knockdown promoted, whereas MIR99AHG overexpression inhibited, cell proliferation, colony formation, migration and invasion. Mechanistically, RNA pulldown followed by mass spectrometry identified SCD1 as a MIR99AHG -associated protein. MIR99AHG depletion did not markedly alter SCD1 mRNA levels, but increased SCD1 protein fluorescence intensity, suggesting post-transcriptional regulation. Functionally, SCD1 knockdown reversed MIR99AHG depletion-induced lipid accumulation, triglyceride production, cell growth, migration and invasion. Together, these findings reveal a MIR99AHG -SCD1 regulatory axis that suppresses lipid biogenesis and malignant progression in lung cancer.

Source: Journal of Cancer Research and Clinical Oncology

DOI: 10.1007/s00432-026-06573-y

Authors: Run Chen, Ping Fang, Xiaojuan Li, Yadi He, Yufeng Wang, Yonghui Wu

Institutions: TCM-Intigrated Cancer Center of Southern Medical University, Southern Medical University, Third Affiliated Hospital of Sun Yat-sen University

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,390