Histological control data in target and non-target organs versus induced findings from 74 amphibian metamorphosis assays (AMAs) using the African clawed frog (Xenopus laevis)
Year: 2026
Type: article
Abstract: Histopathological data from solvent control tadpoles (n=2,065) were compiled from 74 amphibian metamorphosis assay (AMA) studies evaluated at AnaPath Services GmbH between March 2019 and October 2025. The median Nieuwkoop and Faber stage was 59 (range, 55-63) across all control groups. The four core diagnoses (follicular cell hypertrophy or hyperplasia and thyroid hypertrophy or atrophy) for the histopathological evaluation of tadpole thyroid glands in AMA studies were observed at prevalences of <5% in solvent control groups. The low incidence of these core diagnoses reflects consideration of the normal morphology expected at a defined developmental stage. Lesions in non-target tissues of solvent controls were limited in number and variability. Selected treatment-related thyroid gland and non-target organ lesions are included as examples.
Source: Journal of Toxicologic Pathology
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W7204457103