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Additional file 4 of CCL5 and CD11b-fibrin interactions regulate microglia migration and morphology in hyperinflammatory experimental cerebral malaria

Year: 2026
Type: other
Abstract: Supplementary Material 4: Supplemental Figure 4: Intranasal inhibition of CCL5 did not change the fraction of adherent inflammatory monocytes (iMO) in the brain, nor CD4+ T cells, nor systemic T cell cytokines (TNF, IFN-γ ). IL-10 KO mice were infected with P. chabaudi, and mice were treated with Met-CCL5 from 3 to 6 dpi, while the control group was treated with saline. Brains were collected for flow cytometry at 7 dpi. Blood was also collected for cytokine measurement by immuno-bead assay. A) Graph of adherent inflammatory monocytes (CD11b+ CD45hi Ly6C+ MHCII+) and MFI of MHCII on inflammatory monocytes (iMO). B) Graph of �4+/Thy1.2+ T cells. C) Graph shows systemic cytokines TNF and IFN-γ; as an indication of systemic T cell activation. Statistical analyses were performed using an unpaired Student’s t-test; p-value not significant, ns.
Source: Figshare
DOI: 10.6084/m9.figshare.33346703
Authors: Nadia D. Domingo, Olivia D. Solomon, Paula Villarreal, Florentin Aussenac, Difernando Vanegas, Mark Joseph Endrino, Andrew S. Mendiola, Lucinda Puebla-Clark, Komi Gbedande, Astrid E. Cardona, Katerina Akassoglou, Matthew J. Flick, Gracie Vargas, Robin Stephens
Institutions: Prairie View A&M University, The University of Texas Medical Branch at Galveston, The University of Texas at San Antonio, Gladstone Institutes, University of California, San Francisco, University of North Carolina at Chapel Hill, University of Southern Denmark
Subfield: Neurology
Open Access status: green
OpenAlex ID: W7204458691
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