Work

Catalytic application of biological based metal-organic frameworks catalyst with FeCl3 tags in the synthesis of pyrido[2,3-d]pyrimidine derivatives

Year: 2026

Type: article

Abstract: The development of environmentally friendly catalysts with biologically active cores could be a new and unique approach in materials science. With this view, Herein, we have introduced a new attitude for the preparation of biological catalyst based on metal-organic frameworks. For this purpose, novel biological metal-organic frameworks Cu-BTC-histidine functionalized with FeCl 3 as a heterogeneous catalyst. This Bio-MOFs was characterized using various techniques such as FT-IR, X-ray diffraction (XRD), scanning electron microscopy (SEM), TG/DTG analysis and energy dispersive X-ray spectroscopy (EDS). Then, Bio-MOFs was applied in the synthesis of pyrido[2,3- d ]pyrimidine derivatives as a biologically active candidate. It should be noted that the yields of the products synthesized using the aforementioned catalyst are adequate (75–95%) and the reaction times are short (19–40 min.). The favorable activity of this environmentally friendly catalyst was very interesting in preparing these materials under green, mild conditions.

Source: Scientific Reports

DOI: 10.1038/s41598-026-60576-w

Authors: Mina Bakhtiari, Mahmoud Zarei, Hassan Sepehrmansourie

Institution: University of Qom

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: $2,690