Work

Biological heterogeneity in Parkinson’s disease: implications for MRI-based patient stratification

Year: 2026

Type: article

Abstract: Parkinson's disease is increasingly recognized as a heterogeneous syndrome characterized by diverse pathological processes and clinical manifestations. Here, we propose a multidimensional framework to assess this heterogeneity, with each dimension potentially captured using advanced magnetic resonance imaging techniques. The framework comprises dominant pathological processes, spatial distribution patterns of pathology across brain regions, propagation architecture, temporal dynamics of disease progression, co-pathology burden, and system response and resilience mechanisms.

Source: npj Parkinson s Disease

DOI: 10.1038/s41531-026-01544-z

Authors: Marta M. Pokotylo, Norbert Brüggemann, Jannik Prasuhn

Institutions: University of Lübeck, Kennedy Krieger Institute, Johns Hopkins University, Johns Hopkins Medicine, University Hospital Schleswig-Holstein

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890