Work

Verrucous epidermal nevus with epidermolytic hyperkeratosis: Histopathological-dermoscopic correlation

Year: 2026

Type: article

Abstract: Dear Sir, Verrucous epidermal nevi (VEN) are non-inflammatory hamartomatous growths composed of keratinocytes.[1] ey present as velvety, skin-colored to dark brown papules and plaques, appearing along the Blaschko lines.[2] Epidermolytic hyperkeratotic epidermal nevus (EN) is a rare variant showing cutaneous mosaicism.[3] Epidermolytic EN may present at birth, though it may appear as late as adulthood.[4] is variant is classically caused by mutations in the KRT1 and KRT10 genes.[3] While VEN may have a mutation in the FGFR3 gene, the same gene which is responsible for the development of seborrheic keratosis (SK).[2] Dermoscopy of epidermolytic EN shows features similar to those of any other EN, but it can resemble that of SK because of their morphologic similarity.We present a case of epidermolytic VEN with SK-like dermoscopic features.

Source: Cosmoderma

DOI: 10.25259/csdm_153_2026

Authors: Sadhana Raturi, Pritika Nehra

Institution: Max Healthcare

Language: English

Topic: Genetic and rare skin diseases.

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7204470522