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Kinematic analysis of walking and immuno-histological analysis of lesion area following TMP-316, a novel kinase inhibitor, infusion in male Sprague Dawley rats with cervical hemi-contusion injury

Year: 2026

Type: dataset

Abstract: STUDY PURPOSE: The animal experiments reported here are aimed at evaluating the efficacy of a single intrathecal dose of TMP-316 in a rat cervical spinal cord injury model, and determining whether intrathecal TMP-316 induces astrocyte or microglial reactivity in the spinal cord. DATA COLLECTED: The dataset contains animal-level data from two studies. The efficacy study includes vehicle and TMP-316 treatment groups, cervical hemicontusion parameters, longitudinal kinematic assessments from baseline through 42 days post-injury, forelimb gait traces, and spinal cord lesion-area measurements. The neuroinflammation study includes glial fibrillary acidic protein fluorescence intensity and ionized calcium-binding adaptor molecule 1-positive cell density measured in rostral and caudal lumbar spinal cord 14 days after intrathecal administration of vehicle or TMP-316 to uninjured rats. DATA USAGE NOTES:

Source: UC San Diego

DOI: 10.34945/f5xs4d

Authors: Hassan Al-Ali, Abdiel Badillo-Martinez, Bassel Awada, Brian Silver, Omar Elwardany, Ronald Buckle, Graham Johnson, Siyuan Sun, Rodrig Rodrig Lendof, Nikhita Guha, Praveen Singh, Jae Lee, John Bixby, Vance Lemmon

Institutions: University of Miami, Sylvester Comprehensive Cancer Center, Frost Institute for Data Science & Computing

Language: English

Topic: Spinal Cord Injury Research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Buoniconti Fund to Cure Paralysis, State of Florida

OpenAlex ID: W7204471750

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