Year: 2026
Type: article
Abstract: Adolescent cannabis use produces lasting and sex-specific effects into adulthood, although poorly explained mechanistically. This study links these cannabis-induced effects to sex-dependent changes in phosphorylation of mitochondrial Complex I subunit NDUFS4 during adolescence, identifying mitochondrial pathways as causal mechanisms and potential therapeutic targets to reduce their long-term consequences.
Source: Neuropsychopharmacology
Institutions: Université de Bordeaux, Inserm, Neurocentre Magendie, Hospital Del Mar, Hospital del Mar Research Institute, Universidad de Salamanca, Instituto de Investigación Biomédica de Salamanca, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Biología Funcional y Genómica, BoRdeaux Institute of onCology, University of Teramo, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, NutriNeuro, Institut Polytechnique de Bordeaux
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,290
OpenAlex ID: W7204473123