Year: 2026
Type: article
Abstract: Periodontitis, caused by the oral pathobiont Porphyromonas gingivalis (Pg), leads to progressive systemic diseases through oral-organ interactions, including cognitive dysfunction. However, the behavioral and immunological mechanisms underlying the oral-brain axis during the development of periodontitis remain unclear. We found that Pg-induced periodontitis promoted anxiety-like behavior and progressive cognitive dysfunction in mice. While Pg-induced periodontitis drove the accumulation of interleukin (IL)-17A-producing T cells in the mouth, an increased population of Vγ4 + γδ T cells migrate to the brain through the draining cervical lymph nodes via the CCL20/CCR6 pathway. Treatment with an anti-IL-17A antibody, an anti-CCL20 antibody, or anti-TCRγδ antibody ameliorated both anxiety-like behavior and cognitive dysfunction, and suppressed the increased expression of IL-17A receptor in the brain. Collectively, our findings reveal a function beyond its established role for IL-17A in the oral-brain axis that links Pg-induced periodontitis to cognitive dysfunction.
Source: Cell Reports
Institution: Fukuoka Dental College
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,620
Funders: Institute of Development, Aging and Cancer, Tohoku University, Takeda Science Foundation, Institute for Fermentation, Osaka, Japan Agency for Medical Research and Development, Research Promotion Foundation, Kyushu University, Smoking Research Foundation, Shionogi, Kaibara Morikazu Medical Science Promotion Foundation, Terumo Foundation for Life Sciences and Arts, University of the Ryukyus, Promotion and Mutual Aid Corporation for Private Schools of Japan, Japan Society for the Promotion of Science, Shionogi Infectious Disease Research Promotion Foundation
Awards: G15450516, Development of next-generation immunotherapy for periodontal disease through collaboration between intestinal bacteria and biological agents, Investigation of periodontal immune regulation based on microbiome and development of new treatment methods, G2592414919, G2797087372, 歯周病起因性の免疫細胞が認知機能低下症を引き起こすメカニズムの解明, G5227278639, G5792290389, Immunological mechanisms promoting oral and systemic health via the gut–mouth axis, initiated by periodontal therapy, Functional analysis of the signaling adaptor protein during oral candidiasis, ヒトにおける腸－口腔連関として腸内細菌叢が果たす歯周病重症化の免疫学的解明, Analysis of new mechanism of dementia development caused by periodontal disease
OpenAlex ID: W7204479848