Work

Hepatic epithelioid hemangioendothelioma: case report with resection and adjuvant bevacizumab-capecitabine

Year: 2026

Type: article

Abstract: Epithelioid hemangioendothelioma of the liver is a rare vascular hepatic malignancy that often poses a diagnostic challenge. Its morphology appears intermediate between hemangioma and angiosarcoma. The clinical course may be aggressive, although with considerable variability. Surgical excision represents the mainstay of therapy when feasible. Given its rarity, no standard systemic therapy exists for unresectable or metastatic disease, and the role of adjuvant treatment remains undefined. We report the case of a 49-year-old woman with multifocal hepatic epithelioid hemangioendothelioma who underwent extensive surgical resection followed by adjuvant capecitabine and bevacizumab after detection of a micrometastasis in a cystic duct lymph node (pN1). The patient remains disease-free at a follow-up of at least 4 years.

Source: Egyptian Liver Journal

DOI: 10.1186/s43066-026-00533-4

Authors: Ioannis Gavalas, Christos Emmanouilides, George Imvrios, Eleftherios Eleftheriadis, Ioannis Tsanaktsidis

Institutions: G. Papanikolaou General Hospital, Interbalkan Medical Center, 424 General Military Hospital

Language: English

Topic: Vascular Tumors and Angiosarcomas

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7204481405