Year: 2026
Type: article
Abstract: Mediastinal gray zone lymphoma (MGZL) is a rare, predominantly adult hematologic malignancy with pathologic features of both primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkins lymphoma (cHL) [ 1 ].Overlapping pathologic features make MGZL diagnostically challenging.Additionally, treatment regimens are poorly defined given rarity and aggressive clinical course.Adult MGZL is usually managed with PMBLstyle chemotherapy, yet with significantly worse outcomes than PMBL and cHL [ 2,3 ].For relapsed disease, definitive therapy is autologous hematopoietic stem cell transplant (aHSCT) [ 4 ].
Source: Pediatric Blood & Cancer
Institutions: Children's Hospital of Philadelphia, Moffitt Cancer Center
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,640
OpenAlex ID: W7204485571