Work

Jacobs Syndrome Presenting With Delayed Puberty and Central Hypogonadism: A Rare Case Report

Year: 2026

Type: article

Abstract: In some rare instances, patients with 47,XYY syndrome can be short in height, accompanied by hypogonadism without the characteristic tall stature. In cases where there is delayed puberty and unusual growth pattern, a complete endocrine work-up, including GnRH and hCG stimulation tests, along with chromosome studies, is vital.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.73335

Authors: Muhammad Hassaan Javaid, Ayesha Ahmad, Amna Ahmad, Muhammad Ajmal Khamosh, Muhammad Hanzla

Institutions: Khyber Medical University, CMH Kharian Medical College, Liaquat University of Medical & Health Sciences, Sylhet MAG Osmani Medical College

Language: English

Topic: Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820