Synthesis of furan derivatives employing multicomponent reactions of alkyl bromides in aqueous media
Year: 2026
Type: article
Abstract: The reaction of 1, 3-dicarbonyl compounds with ethyl bromopyruvate thus led to dihydrofurans in good yields. Dihydrofurans were converted to the corresponding furan derivatives in the presence of p-toluenesulfonic acid (p-TSA). Under similar conditions, however, the reactions of α-haloketones 3-chloropentane-2, 4-dione and methyl 2-chloro-3-oxobutanoate with 1, 3-dicarbonyl compounds led directly to fused furan derivatives in good yields. While, the reaction of phenacyl bromides with 1, 3-dicarbonyl compounds led to either esters or α-substituted acetophenones in moderate yields.
DOI: 10.82361/1251367
Author: IAU
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W7204491760
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