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Expression of HDAC2 and HDAC8 in the airways of COPD patients is associated with responsiveness to ICS: insights from the HISTORIC study

Year: 2026

Type: article

Abstract: Extract Inhaled corticosteroids (ICS) are widely used in COPD management, although their efficacy varies across patients. In many cases, ICS often provide only modest improvement in lung function and quality of life [1]. Moreover, long-term ICS use is associated with adverse effects such as pneumonia, oral candidiasis and dysphonia [2]. A key challenge, therefore, is identifying reliable biomarkers that predict corticosteroid responsiveness in COPD.

Source: European Respiratory Journal

DOI: 10.1183/13993003.00950-2026

Authors: Eleni Papakonstantinou, Marta Nowak, Spasenija Savic Prince, Daniel Soriano, Leticia Grize, Björn Christian Frye, Sebastian Fähndrich, Viktor H. Koelzer, Daiana Stolz

Institutions: University of Freiburg, University Medical Center Freiburg, University of Zurich, University Hospital Zurich, University of Basel, University Hospital of Basel

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7204493404

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