Copper‐Catalyzed Hydroxylation of Simple Fluoroaryl and Aryl Chlorides: A Route to (Fluoro)phenols
Year: 2026
Type: article
Abstract: A copper‐catalyzed conversion of polyfluoroaryl chlorides to the corresponding phenols was developed. A simple ligand system was applied, as well as potassium carbonate as an inexpensive and effective base, while significantly suppressing competing S N Ar pathways. The generality of the method was further demonstrated with simple aryl chlorides, which also underwent efficient hydroxylation. Mechanistic studies suggest that the reaction proceeds via a Cu(I)/Cu(III) catalytic cycle. Notably, the use of a sulfolane/water solvent system enabled high reactivity at a low catalyst loading, underscoring the practicality and scalability of this protocol.
DOI: 10.1002/ejoc.70806
Institutions: Heidelberg University, BASF (Germany)
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Funder: Universität Heidelberg
OpenAlex ID: W7204495161