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Severe Multiorgan Failure Triggered by Infection in an Adult With Decades of Untreated Sickle Cell Disease: A Case Report

Year: 2026

Type: article

Abstract: A 67-year-old man with decades of untreated sickle cell disease developed septic shock with multiorgan failure, splenic infarction, and marrow fibrosis; his genotype could not be confirmed. He recovered with intensive supportive care, with hydroxyurea initiated for long-term disease modification, illustrating catastrophic infection-triggered decompensation despite prolonged clinical quiescence.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.73113

Authors: Sara Shahidi, Gisha Mohan

Institution: Community Health Systems - Tennova North Knoxville Medical Center

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820