Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling
Year: 2026
Type: article
Source: Cell
Authors: Deepali L. Kundnani, Yeunsoo Lee, Taehwan Yang, Tyler P. Warner, Francisco Martinez-Figueroa, Tejasvi Channagiri, Penghao Xu, Ryan A. Eckerty, Mo Sun, Supreet Randhawa, Youngkyu Jeon, Stefania Marsili, Gary Newnam, Yilin Lu, Miharu Yasumuro, Ashlesha Gogate, Vivian S. Park, Sijia Tao, Justin A. Ling, Ryohei Chiba, Hiroyoshi Matsumura, Ryo Uehara, Jonathan M. Fogg, Lynn Zechiedrich, Raymond F. Schinazi, Zachary F. Pursell, Abdulmelik Mohammed, Patricia L. Opresko, Bret D. Freudenthal, Baek Kim, Soojin V. Yi, Nataša Jonoska, Francesca Storici
Institutions: Georgia Institute of Technology, University of South Florida, Tulane University, Emory University, Children's Healthcare of Atlanta, University of Kansas, The University of Kansas Cancer Center, Ritsumeikan University, Baylor College of Medicine, San Jose State University, University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, University of California, Santa Barbara
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: National Science Foundation, Howard Hughes Medical Institute, W. M. Keck Foundation, Georgia Institute of Technology, G. Harold and Leila Y. Mathers Foundation, Mark Foundation For Cancer Research, National Institutes of Health, National Institute of Mental Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Environmental Health Sciences
Awards: G2871399071, Collaborative Research: FTE: Medium: Three Dimensional Algorithmic Assembly and Information Storage, Ribose-seq profile and analysis of ribonucleotides in DNA of oxidatively-stressed and cancer cells, Towards Suppression and Elimination of HIV in the CNS, Collaborative Research: URoL: Epigenetics 2: Epigenetics in Development and Evolution of Primate Brains, DMS/NIGMS 2: Collaborative Research: Modeling R-Loop Formation and Topology Using Braids and Graphs Coupled with Single-Molecule Footprinting, Human Specific Brain DNA Methylation and Neuropsychiatric Diseases, Ribonucleotide Processing in Telomere Maintenance and Integrity, Lentivirus Replication Strategy and Pathogenesis, SAMHD1 mediated dNTP regulation and HIV in myeloid cells, Harnessing Supercoiling to Regulate DNA Activity
OpenAlex ID: W7204523332