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Analysis of Double-Lumen Irrigation-Suction Tube in Patients With Severe Acute Pancreatitis Complicated by Acute Respiratory Distress Syndrome: A Single-Center Exploratory Retrospective Study Using Propensity Score Matching

Year: 2026

Type: article

Abstract: BACKGROUND Severe acute pancreatitis (SAP) complicated by acute respiratory distress syndrome (ARDS) features high mortality. This study aimed to clarify the clinical role of the double-lumen irrigation-suction tube (DLIST) in this patient population. MATERIAL AND METHODS This single-center retrospective study enrolled a total of 101 patients with SAP-ARDS from January 2020 to December 2025. After exclusion, 91 patients were eligible for analysis and divided into 2 groups: the DLIST group and a standard care group. Propensity score matching was used to balance age. Clinically observed outcomes were 28-, 60-, and 90-day all-cause mortality and ventilator-free days. Cox regression was applied to estimate the association between the DLIST intervention and mortality. RESULTS We performed 1: 1 optimal pair matching without replacement. After propensity score matching, an age-matched cohort of 70 patients (35 pairs) was obtained. Compared with the standard care group, the DLIST group had lower 28-day (20.0% vs 54.3%, P=0.003), 60-day (28.6% vs 60.0%, P=0.008), and 90-day (34.3% vs 60.0%, P=0.031) all-cause mortality, and more ventilator-free days at day 28 (12±8 vs 8±9 days, P=0.041). Multivariable Cox regression showed that DLIST was independently associated with lower 90-day mortality (adjusted HR=0.29, 95% CI 0.13-0.62, P=0.002). CONCLUSIONS This exploratory retrospective cohort study indicates that early DLIST within 14 days of SAP symptom onset may be associated with short-term clinical outcomes among patients with SAP complicated by ARDS. However, prospective multicenter randomized trials are necessary to verify causality, identify the optimal timing, screen appropriate candidates, and formulate standardized procedures.

Source: Medical Science Monitor

DOI: 10.12659/msm.954009