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Large-scale proteomics to identify novel biomarkers linking social determinants of health to heart failure risk

Year: 2026
Type: article
Abstract: Adverse social determinants of health (SDOH) associate with greater heart failure (HF) risk. Among 9879 community-based participants of the Atherosclerosis Risk in Communities (ARIC) cohort study, we assessed 4955 plasma proteins using an aptamer-based platform (SomaLogic). We derived an SDOH factor comprising income, education, and area deprivation index (ADI) in Black and white participants. Proteins associated with this factor at Bonferroni significance were tested for associations with incident HF using multivariable Cox proportional hazard models. Among Black participants, 36 proteins were associated with both the SDOH factor and incident HF, 126 were among white participants, and 12 were shared between race strata. Eight of these demonstrated significant mediation effect in causal mediation models. Key results were replicated in 49,396 participants in UK Biobank. Mendelian randomization and colocalization suggested a potentially causal effect of C1q tumor necrosis factor–related protein 1 (C1QTNF1), an adiponectin paralog, on HF. We demonstrate protein biomarkers associated with SDOH burden and HF risk.
DOI: 10.17615/y53s-4e45
Authors: Odden, Michelle C., Lamberson, Victoria, Bhavsar, Nrupen, Yang, Yimin, Leonard, Tammy, Shah, Amil M., Powell-Wiley, Tiffany M., Floyd, James S., Coresh, Josef, Zierath, Rani, Ndumele, Chiadi, Ramonfaur, Diego, Chang, Patricia P., Yu, Bing, Butler, Kenneth, Claggett, Brian, Bey, Ganga, Walker, Keenan A., Kucharska-Newton, Anna
Field: Medicine
Open Access status: green
Funders: Support for Pioneering Research Initiated by the Next Generation, Chinese University of Hong Kong, Shenzhen, Howard Hughes Medical Institute, National Aeronautics and Space Administration, Bill and Melinda Gates Foundation, Welch Foundation, Bristol-Myers Squibb Foundation, Knights Templar Eye Foundation, Research Corporation for Science Advancement, Whitehall Foundation, California State Water Resources Control Board, American Mathematical Society, UNICEF, Georgia Institute of Technology, California Institute of Technology, Univerzita Karlova v Praze, Naito Foundation, Takeda Science Foundation, Michigan State University, Uehara Memorial Foundation, Japan Agency for Medical Research and Development, National Center for Global Health and Medicine, Simons Foundation Autism Research Initiative, Chan Zuckerberg Initiative, Precise Measurement Technology Promotion Foundation, Perlman Family Foundation, Tromsø Forskningsstiftelse, Kanagawa Institute of Industrial Science and Technology, Punjab Agriculture Research Board, Massachusetts Green High Performance Computing Center, Japan Health Research Promotion Bureau, Agency for Science, Technology and Research, National University of Singapore, National Research Foundation Singapore, Council of Scientific and Industrial Research, India, Ministry of Education - Singapore, Nanyang Technological University, Boehringer Ingelheim Fonds, Minerva Foundation, Deutsche Forschungsgemeinschaft, National Natural Science Foundation of China, Ministerstvo Školství, Mládeže a Tělovýchovy, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Chinese Academy of Sciences, China Postdoctoral Science Foundation, Natural Science Foundation of Fujian Province, Hattori Hokokai Foundation, Queensland Government, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Guangdong Medical Research Foundation, Israel Science Foundation, Kato Memorial Bioscience Foundation, Vetenskapsrådet, Ministry of Education and Science of the Republic of Kazakhstan, Deanship of Scientific Research, King Faisal University, Department of Science and Technology of Sichuan Province, Natural Science Foundation of Chongqing, Norges Forskningsråd, Ministerstvo Kultury, Bangladesh Council of Scientific and Industrial Research, Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii, Uppsala Universitet, Università degli Studi di Verona, Natural Science Foundation of Shandong Province, Astellas Foundation for Research on Metabolic Disorders, Iketani Science and Technology Foundation, SENSHIN Medical Research Foundation, Waksman Foundation of Japan, Puerto Rico Science, Technology and Research Trust, Novo Nordisk Fonden, Makerere University, Higher Education Commision, Pakistan, Hefei University, Key Research and Development Program of Jiangxi Province, Rising Tide Foundation, Natural Science Foundation of Sichuan Province, Zunyi Normal University, Natural Science Foundation for Young Scientists of Shanxi Province, National Institutes of Health, Centers for Disease Control and Prevention, Defense Advanced Research Projects Agency, Defense Threat Reduction Agency, Bureau of Reclamation, Uniformed Services University of the Health Sciences, Center for Environmental Microbial Interactions, California Institute of Technology, Directorate for STEM Education, Economic and Social Research Council, National Health and Medical Research Council, National Medical Research Council, Japan Society for the Promotion of Science, Japan Science and Technology Agency, Consejo Superior de Investigaciones Científicas, Natural Science Foundation of Anhui Province, Instituto de Salud Carlos III, Beijing Nova Program, Guangzhou Municipal Science and Technology Project, Erasmus+, National Key Research and Development Program of China, Shanxi Provincial Key Research and Development Project, West China Hospital, Sichuan University, Basic and Applied Basic Research Foundation of Guangdong Province, Deanship of Scientific Research, Princess Nourah Bint Abdulrahman University, National Institute on Alcohol Abuse and Alcoholism, National Heart, Lung, and Blood Institute, Office of Naval Research, National Institute on Drug Abuse, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Institute of Child Health and Human Development, National Institute of Dental and Craniofacial Research, National Institute on Disability, Independent Living, and Rehabilitation Research, Liver Center, University of California, San Francisco, Stanford Maternal and Child Health Research Institute, Air Force Office of Scientific Research, HORIZON EUROPE Marie Sklodowska-Curie Actions, Centre d'étude de la biodiversité amazonienne, Chemo-Sero-Therapeutic Research Institute
OpenAlex ID: W7204548938
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