Data associated with the publication: Hyper-intense tumor peripheral accumulation of antibody-conjugated iron oxide nanoparticles can enable breast cancer detection by magnetic particle imaging
Year: 2026
Type: dataset
Abstract: This dataset contains all raw data associated with the publication entitled “Hyper-intense tumor peripheral accumulation of antibody-conjugated iron oxide nanoparticles can enable breast cancer detection by magnetic particle imaging.” In this study, we report observations that tumor specific antibody conjugated nanoparticles tend to be sequestered by phagocytic cells in the TME, rather than by cancer tumor cells. Indeed, we found no evidence of the latter. Therefore, both non-specific and tumor specific antibody coated nanoparticles were engulfed in similar quantities by inflammatory cells residing in the vicinity of tumors, micrometastases, and organs of the reticuloendothelial system, in comparatively similar amounts. Unconjugated nanoparticles, however, were predominantly sequestered by the larger organs of the reticuloendothelial system. We saw a substantial amount of antibody-conjugated nanoparticles accumulating in TME that enabled non-invasive detection of tumors by magnetic particle imaging (MPI). We also observed that MPI differentiates between tumor and wound-associated inflammation because of differing patterns of nanoparticle distribution. These findings hold promise for developing iron oxide nanoparticle-enabled MPI as a new modality for detecting tumors and metastases.
DOI: 10.7281/t1dadmsk
Institution: Johns Hopkins University
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7204573446
Cites:
Cited by:
Related to: